| Title | [Effect of sublingual oxybutynin in postoperative pain after radical retropubic prostatectomy.] | | Author(s) | Callier C, Tauzin-Fin P, Bram R, Ballanger P | | Institution | Service d'urologie, groupe hospitalier Pellegrin, CHU Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. | | Source | Prog Urol 2009 Sep; 19(8):558-62. | | Abstract | INTRODUCTION: Total prostatectomy (TP) is one of the referential treatments of localized cancer of the prostate gland. Urethrovesical anastomosis and urinary catheterization may be sources of strong contractions of the detrusor muscle responsible for intense pain which is added to parietal pain. This study evaluates the efficiency of oxybutynin in the treatment of this postoperative pain (POP). MATERIAL AND
METHOD: Forty-five patients due to benefit from a TP by laparotomy were included in this prospective study. A urinary catheter was put in place during the operation. Patients were randomly split into two groups in the postoperative care room. Group P (n=23) received a placebo in tablet form and group O (n=22) received 5mg of oxybutynin in sublingual form. The POP was evaluated every 2hours using the Visual Analogue pain Scale (VAS 0:10).
RESULTS: The accumulated dose of tramadol after 8hours was 110.8mg in group P and 39.7mg in group O (p<0.05). For group P, 15/23 of the patients (65%) were in pain versus 4/22 (18%) in group O. The VAS scores of group P were higher (4.1+/-1) than those of group O (1.2+/-0.9). For group P, when the PCA dose of tramadol was inefficient, a tablet of oxybutynin 5mg brought the VAS scores down to the same level of those of group O within 2hours. No side effects linked to the antimuscarinic action were observed.
CONCLUSION: Oxybutynin given in sublingual form reduced, at postoperative stage, the frequency and intensity of pain linked to the bladder wound and to the catheter after TP. Its use for the POP of the bladder section reduced the consumption of postoperative analgesia. | | Language | fre | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19699454 |
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